Population
Euvolemic 6- and 11- to 14-week-old spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
Comparison
Tubular microperfusion (loop perfusion) vs No loop perfusion and normotensive Wistar-Kyoto…
Design
Preclinical
Authors
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No direct clinical implications; leaves open whether enhanced TGF contributes to early human hypertension.
Young spontaneously hypertensive rats exhibit enhanced tubuloglomerular feedback activity compared to normotensive controls, suggesting a role in the early development of hypertension.
Dilley et al. (1984) studied this question.