Population
Anesthetized spontaneously hypertensive rats and Wistar-Kyoto rats, and Milan hypertensive and Milan…
Comparison
Intratubular infusion of N… vs Control conditions and normotensive rat strains
Design
Preclinical
Authors
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Impaired TGF-NO signaling in hypertensive rat models; leaves open relevance to human hypertension and requires clinical translation studies.
The effect of intratubular NO synthase inhibition on tubuloglomerular feedback is significantly impaired in hypertensive rat models compared to normotensive controls.
Thorup et al. (1996) studied this question.
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