Key result
An intrarenal NO clamp markedly increased tubuloglomerular feedback responsiveness (deltaSFP 19.6 vs 5.7 mmHg, P<0.05), suggesting dynamic NO release mitigates the normal TGF response.
Why the study?
Does dynamic release of nitric oxide mitigate the tubuloglomerular feedback response in Sprague Dawley rats?
Population
Sprague Dawley rats
Comparison
Intrarenal NO clamp and intrarenal angiotensin… vs Untreated animals
Design
Preclinical
Authors
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Confirms dynamic NO mitigates TGF in rats; leaves open translation to human renal autoregulation.
Does dynamic release of nitric oxide mitigate the tubuloglomerular feedback response in Sprague Dawley rats?
Absolute Event Rate: 19.6% vs 5.7%
p-value: p=< 0.05
Dynamic release of nitric oxide during tubuloglomerular feedback activation mitigates the TGF response, offsetting the action of a primary vasoconstrictor mediator.
Turkstra et al. (1998) studied Tubuloglomerular feedback responsiveness. Intrarenal NO clamp vs. Untreated animals was evaluated on Fall in tubular stop flow pressure (deltaSFP) (p=< 0.05). An intrarenal NO clamp markedly increased tubuloglomerular feedback responsiveness (deltaSFP 19.6 vs 5.7 mmHg, P<0.05), suggesting dynamic NO release mitigates the normal TGF response.
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