Key result
In rabbit afferent arterioles, addition of the nNOS inhibitor 7-NI increased tubuloglomerular feedback from 2.3 to 3.5 microm (P<0.02), indicating NO from THAL NOS inhibits TGF.
Population
Rabbit afferent arterioles and attached macula densa microperfused in vitro
Comparison
Perfusion with nNOS inhibitor 7-nitroindazole… vs Baseline measurements before increasing NaCl, or…
Design
Preclinical
Authors
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May modulate TGF via tubular NO; leaves open relevance to human renal autoregulation.
Absolute Event Rate: 3.5% vs 2.3%
p-value: p=<0.02
Nitric oxide produced by THAL NOS acts as a paracrine factor that reaches the macula densa and inhibits tubuloglomerular feedback.
Wang et al. (2002) studied this question. 7-nitroindazole (7-NI) and L-NAME vs. Baseline was evaluated on Tubuloglomerular feedback (TGF) response (afferent arteriole diameter change in micrometers) (p=<0.02). In rabbit afferent arterioles, addition of the nNOS inhibitor 7-NI increased tubuloglomerular feedback from 2.3 to 3.5 microm (P<0.02), indicating NO from THAL NOS inhibits TGF.
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