April 27, 2016Open Access

Acceptable Analytical Variation May Exceed High-Sensitivity Cardiac Troponin I Cutoffs in Early Rule-Out and Rule-In Acute Myocardial Infarction Algorithms

PKPeter A. KavsakGeneral Cardiology ADAndrew Don-WauchopeMcMaster University SHStephen HillUniversity of Oxford

Key Result

Citrate-fluoride-EDTA (CFE) tubes are recommended over fluoride-EDTA (FE) tubes for maternal glucose measurement in the diagnosis of gestational diabetes mellitus.

Structured PICO

Does the use of CFE tubes compared to FE tubes improve the measurement of maternal glucose for the diagnosis of GDM?

Population

Maternal patients undergoing glucose measurement for the diagnosis of gestational diabetes mellitus (GDM)

Intervention

CFE tubes for blood collection

Comparator

FE tubes

Outcome

Measurement of maternal glucose for the diagnosis of GDMsurrogate

CFE tubes are recommended over FE tubes for maternal glucose measurement to diagnose gestational diabetes, likely due to better stability during the phlebotomy-cell separation interval.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

we recommend that in contemporary obstetrics the use of FE tubes be replaced by CFE tubes for the measurement of maternal glucose for the diagnosis GDM. This is particularly important for the fasting sample because in reality the phlebotomy-cell separation interval is longest.

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