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The metabolism of 2'-(14)Cnicotine given as an intravenous injection in small doses to anaesthetized and unanaesthetized cats has been studied. A method is described for the quantitative determination of (14)Cnicotine and (14)Ccotinine in tissues and body fluids. Nanogram amounts of these compounds have been detected. After a single dose of 40mug. of (14)Cnicotine/kg., 55% of the injected radioactivity was excreted in the urine within 24hr., but only 1% of this radioactivity was unchanged nicotine. (14)CNicotine is metabolized extremely rapidly, (14)Ccotinine appearing in the blood within 2.5min. of intravenous injection. (14)CNicotine accumulates rapidly in the brain and 15min. after injection 90% of the radioactivity still represents (14)Cnicotine. Metabolites of (14)Cnicotine have been identified in liver and urine extracts. (14)CNicotine-1'-oxide has been detected in both liver and urine.
David M. Turner (Mon,) studied this question.