Does intravenous fluid therapy with bicarbonate and/or mannitol improve outcomes compared to intravenous fluid therapy alone in patients with rhabdomyolysis?
This systematic review highlights the lack of randomized controlled trials comparing intravenous fluid therapy alone versus with bicarbonate and/or mannitol for the treatment of rhabdomyolysis.
Most studies defined rhabdomyolysis based on creatine kinase values five times above the upper limit of normal. Etiologies differ among the adult and pediatric populations and no randomized controlled trials have been done to compare intravenous fluid therapy alone versus intravenous fluid therapy with bicarbonate and/or mannitol.
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Critical Care
Hebrew University of Jerusalem
Shaare Zedek Medical Center
Universidad Autónoma de Baja California
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Chavez et al. (Wed,) studied this question.