Why the study?
Does intravenous fluid therapy with bicarbonate and/or mannitol improve outcomes compared to intravenous fluid therapy alone in patients with rhabdomyolysis?
Population
Adult and pediatric populations with rhabdomyolysis
Comparison
Intravenous fluid therapy with bicarbonate… vs Intravenous fluid therapy alone
Design
Systematic_review
Authors
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No RCTs guide bicarbonate/mannitol use in rhabdomyolysis; leaves open whether they improve outcomes over fluids alone.
Does intravenous fluid therapy with bicarbonate and/or mannitol improve outcomes compared to intravenous fluid therapy alone in patients with rhabdomyolysis?
This systematic review highlights the lack of randomized controlled trials comparing intravenous fluid therapy alone versus with bicarbonate and/or mannitol for the treatment of rhabdomyolysis.
Chavez et al. (2016) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: