Overexpression of IL-18 in fructose-fed rats significantly increased collagen volume fraction (8.43% vs 6.78%) and aggravated left ventricular diastolic dysfunction compared to control.
Does intravenous administration of an adenovirus encoding rat IL-18 aggravate left ventricular remodeling and diastolic dysfunction in male Wistar rats fed 10% fructose?
Overexpression of IL-18 aggravates left ventricular remodeling and diastolic dysfunction in a rat model of metabolic syndrome, highlighting inflammation as a potential therapeutic target for metabolic cardiomyopathy.
Absolute Event Rate: 8.43% vs 6.78%
p-value: p=<0.05
Inflammation plays an important role in the pathophysiology of the metabolic syndrome (MS). We determined whether the overexpression of interleukin (IL)-18 could aggravate left ventricular (LV) remodeling and diastolic dysfunction in fructose-fed rats (FFRs). To create an animal model for MS, male Wistar rats received 10% fructose in water for 8 months. We used an adenovirus encoding rat IL-18 to overexpress IL-18 in FFRs by intravenous administration. IL-18 overexpression led to increases in collagen volume fraction and collagen deposition. LV systolic function was unaltered. But the LV end-diastolic pressure and the time constant of isovolumic relaxation (tau) were increased. Peak negative value of time derivative of LV pressure (-dp/dt) was decreased. Isovolumic relaxation time and myocardial index, as assessed by echocardiography, were increased. Overexpression of IL-18 leads to aggravated LV remodeling and dysfunction in FFRs. Attenuation of the inflammatory process may provide a novel therapeutic strategy in treating metabolic cardiomyopathy.
Xing et al. (Mon,) conducted a other in Metabolic syndrome and cardiac fibrosis (n=43). Adenovirus carrying the IL-18 gene (Ad-IL-18) vs. Adenovirus containing the GFP gene (Ad-GFP) was evaluated on Collagen volume fraction (p=<0.05). Overexpression of IL-18 in fructose-fed rats significantly increased collagen volume fraction (8.43% vs 6.78%) and aggravated left ventricular diastolic dysfunction compared to control.