Intermittent, but not continuous, hypoxia induced ventilatory long-term facilitation (increased VE and VE/VCO2) in unanesthetized rats 60 minutes post-exposure.
Does intermittent hypoxia induce ventilatory long-term facilitation in unanesthetized rats compared to continuous hypoxia?
Unanesthetized rats exhibit ventilatory long-term facilitation after intermittent, but not continuous, hypoxia.
We tested the hypothesis that unanesthetized rats exhibit ventilatory long-term facilitation (LTF) after intermittent, but not continuous, hypoxia. Minute ventilation (VE) and carbon dioxide production (VCO(2)) were measured in unanesthetized, unrestrained male Sprague-Dawley rats via barometric plethysmography before, during, and after exposure to continuous or intermittent hypoxia. Hypoxia was either isocapnic inspired O(2) fraction (FI(O(2))) = 0.08--0.09 and inspired CO(2) fraction (FI(CO(2))) = 0.04 or poikilocapnic (FI(O(2)) = 0.11 and FI(CO(2)) = 0.00). Sixty minutes after intermittent hypoxia, VE or VE/VCO(2) was significantly greater than baseline in both isocapnic and poikilocapnic conditions. In contrast, 60 min after continuous hypoxia, VE and VE/VCO(2) were not significantly different from baseline values. These data demonstrate ventilatory LTF after intermittent hypoxia in unanesthetized rats. Ventilatory LTF appeared similar in its magnitude (after accounting for CO(2) feedback), time course, and dependence on intermittent hypoxia to phrenic LTF previously observed in anesthetized, vagotomized, paralyzed rats.
Olson et al. (Wed,) reported a other. Intermittent hypoxia vs. Continuous hypoxia and baseline was evaluated on Minute ventilation (VE) and VE/VCO2 60 minutes after exposure. Intermittent, but not continuous, hypoxia induced ventilatory long-term facilitation (increased VE and VE/VCO2) in unanesthetized rats 60 minutes post-exposure.