Does suppression of the Wnt/β-catenin to c-Myc axis prevent or treat abnormal cardiac remodeling in heart failure?
Suppression of the Wnt/β-catenin to c-Myc axis represents a potential therapeutic target for preventing and treating heart failure.
This study indicates that TCF7L2 mediates canonic Wnt/β-catenin signaling and c-Myc upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt/β-catenin to c-Myc axis can be explored for preventing and treating heart failure.
Hou et al. (Wed,) studied this question.