Why the study?
Does suppression of the Wnt/β-catenin to c-Myc axis prevent or treat abnormal cardiac remodeling in heart failure?
Does suppression of the Wnt/β-catenin to c-Myc axis prevent or treat abnormal cardiac remodeling in heart failure?
Suppression of the Wnt/β-catenin to c-Myc axis represents a potential therapeutic target for preventing and treating heart failure.
May identify Wnt/β-catenin suppression as a target in experimental HF; leaves open clinical translation.
This study indicates that TCF7L2 mediates canonic Wnt/β-catenin signaling and c-Myc upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt/β-catenin to c-Myc axis can be explored for preventing and treating heart failure.
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Hou et al. (2016) studied this question.
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