Key points are not available for this paper at this time.
PhaSeal is a containment system designed to ensure the safe preparation and administration of cytostatic drugs and thus reduce environmental contamination to work areas and to medical and support staff. The PhaSeal system was tested in an outpatient setting in Sweden for 1 year during the preparation and administration of cyclophosphamide, fluorouracil, and similar cytostatic drugs. The study was designed to determine the effectiveness of PhaSeal in preventing the leakage of cytostatic drugs frequently reported in a number of studies. Cytostatic drugs were prepared and administered using standard safety procedures, except that a biological safety cabinet was not used. At the conclusion of the study period, environmental contamination was determined from wiping samples of objects and surfaces in the drug preparation room. Neither cyclophosphamide nor fluorouracil was found in any of these samples. Results show that use of the PhaSeal system alone is sufficient to prevent environmental contamination during the preparation of cytostatic drugs.
Sessink et al. (Mon,) studied this question.