Endothelial function assessed by maximum flow-mediated dilatation was significantly worse in hypertensive diabetic patients with diastolic dysfunction (7.15%) compared to those with normal diastolic function (11.85%).
Cross-Sectional (n=34)
No
Is diastolic dysfunction associated with worse endothelial function in patients with type 2 diabetes and hypertension?
In patients with type 2 diabetes and hypertension, the presence of diastolic dysfunction is associated with worse endothelial function as measured by flow-mediated dilatation.
Absolute Event Rate: 7.15% vs 11.85%
p-value: p=0.004
BACKGROUND: Endothelial dysfunction may be involved in the pathophysiology of cardiac abnormalities in patients with diabetes mellitus (DM). A correlation between endothelial dysfunction and diastolic dysfunction in patients with type 1 DM has been demonstrated, but this relationship has not been well investigated in type 2 DM. OBJECTIVE: Compare groups of patients with type 2 DM and hypertension with and without diastolic dysfunction using endothelial function indexes, and to assess whether correlations exist between the diastolic function and the endothelial function indexes. METHOD: This was a cross-sectional study of 34 men and women with type 2 DM and hypertension who were aged between 40 and 70 years and were categorized based on assessments of their Doppler echocardiographic parameters as having normal (14 patients) and abnormal (20 patients) diastolic function. Flow-mediated dilatation (FMD) assessments of the brachial artery evaluated the patients' endothelial function. RESULTS: The mean maximum FMD was 7.15 ± 2.80% for the patients with diastolic dysfunction and it was 11.85 ± 4.77% for the patients with normal diastolic function (p = 0.004). Correlations existed between the maximum FMD and the E/e' ratio (p = 0.040, r = -0.354) and the early wave velocity (e') at the lateral mitral annulus (p = 0.002, r = 0.509). CONCLUSION: The endothelial function assessed by FMD was worse in hypertensive diabetic patients with diastolic dysfunction. There were correlations between the diastolic function indexes and the endothelial function indexes in our sample.
Bedirian et al. (Mon,) conducted a cross-sectional in Type 2 Diabetes and Hypertension (n=34). Diastolic dysfunction vs. Normal diastolic function was evaluated on Maximum flow-mediated dilatation (FMD) (p=0.004). Endothelial function assessed by maximum flow-mediated dilatation was significantly worse in hypertensive diabetic patients with diastolic dysfunction (7.15%) compared to those with normal diastolic function (11.85%).