Does an angiotensin-converting enzyme inhibitor or calcium channel blocker compared to a diuretic prevent major forms of CVD in high-risk hypertensive patients?
High-risk hypertensive patients
Angiotensin-converting enzyme inhibitor or calcium channel blocker
Thiazide-type diuretic
Major forms of cardiovascular disease (CVD)hard clinical
Thiazide-type diuretics are superior to ACE inhibitors or calcium channel blockers in preventing major CVD events in high-risk hypertensive patients and should be preferred for first-step therapy.
Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive. They should be preferred for first-step antihypertensive therapy.
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The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group
JAMA
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The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (Wed,) studied this question.
synapsesocial.com/papers/69daf0b437b5141e3ba3cb96 — DOI: https://doi.org/10.1001/jama.288.23.2981