Why the study?
Does an angiotensin-converting enzyme inhibitor or calcium channel blocker compared to a diuretic prevent major forms of CVD in high-risk hypertensive patients?
Does an angiotensin-converting enzyme inhibitor or calcium channel blocker compared to a diuretic prevent major forms of CVD in high-risk hypertensive patients?
Thiazide-type diuretics are superior to ACE inhibitors or calcium channel blockers in preventing major CVD events in high-risk hypertensive patients and should be preferred for first-step therapy.
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Thiazide-type diuretics merit first-line preference in high-risk hypertension; confirms superiority over ACE inhibitors and calcium channel blockers for major CVD prevention.
Thiazide-type diuretics are superior in preventing 1 or more major forms of CVD and are less expensive. They should be preferred for first-step antihypertensive therapy.
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The ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group (2002) studied this question.
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