Does myocardial external efficiency differ in aortic stenosis patients with reduced contractile function or paradoxical low-flow, low-gradient AS compared to those with preserved function?
Patients with aortic valve stenosis (AS) with and without heart failure, including subgroups with left ventricular ejection fraction <50%, global longitudinal strain greater than -12%, or paradoxical low-flow, low-gradient AS.
Myocardial oxygen consumption (MVO2) and myocardial external efficiency (MEE)surrogate
Reduced myocardial external efficiency in AS patients with reduced contractile function or paradoxical low-flow, low-gradient AS suggests mitochondrial uncoupling may contribute to their poor prognosis.
AS patients display a persistent ability to maintain normal MVO2 and MEE (ie, the ability to convert energy into stroke work); however, patients with left ventricular ejection fraction <50%; global longitudinal strain greater than -12%; or paradoxical low-flow, low-gradient AS demonstrate reduced MEE. These findings suggest that mitochondrial uncoupling contributes to the dismal prognosis in patients with reduced contractile function or paradoxical low-flow, low-gradient AS.
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Nils Henrik Hansson
Heart Failure / Cardiomyopathy
Jens Nørkær Sørensen
Technical University of Denmark
Hendrik J. Harms
Cardiac Imaging
SHILAP Revista de lepidopterología
Journal of the American Heart Association
Aarhus University Hospital
Regional Hospital Horsens
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Hansson et al. (Thu,) studied this question.
synapsesocial.com/papers/69d5723575589c71d767e5fc — DOI: https://doi.org/10.1161/jaha.116.004810
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