Direct oral anticoagulants and warfarin showed a similar incidence of left atrial appendage thrombi (overall prevalence 2.7%) in Japanese patients with non-valvular atrial fibrillation.
Observational
Does DOAC compared to warfarin reduce the prevalence of LAA thrombi in Japanese NVAF patients undergoing preprocedural TEE?
LAA thrombi are present in 2.7% of Japanese NVAF patients on anticoagulation prior to procedures, with similar rates between DOACs and warfarin.
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia, associated with increased cardiovascular morbidity and mortality including thromboembolic events. The aims of this study were to assess the prevalence of left atrial appendage (LAA) thrombi in Japanese non-valvular atrial fibrillation (NVAF) patients undergoing preprocedural transesophageal echocardiography (TEE) during anticoagulation therapy, and to compare the efficacy of warfarin and direct oral anticoagulants (DOAC). METHODS AND RESULTS: -VASc score were all associated with LAA thrombi. On multivariate analysis, BNP ≥173 pg/mL remained the only independent predictor of LAA thrombi. CONCLUSIONS: LAA thrombi were found in 2.7% of Japanese NVAF patients scheduled for procedures despite ongoing oral anticoagulation therapy. Incidence of thrombi was similar for patients on DOAC and on warfarin.
Kawabata et al. (Sun,) conducted a observational in Non-valvular atrial fibrillation. Direct oral anticoagulants (DOAC) vs. Warfarin was evaluated on Prevalence of left atrial appendage (LAA) thrombi. Direct oral anticoagulants and warfarin showed a similar incidence of left atrial appendage thrombi (overall prevalence 2.7%) in Japanese patients with non-valvular atrial fibrillation.
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