A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Key Points

• The aim is to explore how a conserved NAD+ binding pocket affects protein-protein interactions, particularly during aging.
• Identified a specific NAD+ binding pocket regulating interactions among proteins.
• Evaluated the effects of modulating these interactions on aging-related processes.
• Enhanced protein-protein interactions correlated with reduced aging markers, with a significant effect size (p<0.05).
• Modulation was linked to lower incidence rates of cancer and improved resilience to radiation exposure.