Brief myocardial ischemia in swine produced cardiac troponin I elevations and focal myocyte apoptosis at 60 minutes without pathological evidence of infarction.
percentile for normals 60-minutes after reperfusion and rose to readily detectable levels 24-hours later. While tissue analysis at 60-minutes showed no evidence of infarction, TUNEL staining demonstrated isolated myocytes undergoing apoptosis, which was absent after 24-hours. These results demonstrate that cTnI elevations occur after ischemia of a duration that is insufficient to produce myocyte necrosis and reflect myocyte injury associated with delayed apoptosis in the absence of pathological evidence of infarction.
Weil et al. (Wed,) conducted a other in Myocardial Ischemia. Brief myocardial ischemia was evaluated on Cardiac Troponin I release and myocyte apoptosis. Brief myocardial ischemia in swine produced cardiac troponin I elevations and focal myocyte apoptosis at 60 minutes without pathological evidence of infarction.