What is the clinical evidence from this study?

Population: Myocardial Ischemia. Intervention: Brief myocardial ischemia. Primary outcome: Cardiac Troponin I release and myocyte apoptosis.

What question did this study set out to answer?

To evaluate whether brief myocardial ischemia triggers cardiac troponin I release and cellular injury in the absence of true myocardial infarction.

March 29, 2017JACC Basic to Translational ScienceOpen Access

Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine

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Key result

Brief myocardial ischemia in swine triggers troponin I elevation and myocyte apoptosis without pathological infarction.

Key Points

To evaluate whether brief myocardial ischemia triggers cardiac troponin I release and cellular injury in the absence of true myocardial infarction.
Examined swine subjected to brief myocardial ischemia followed by reperfusion, measuring circulating cardiac troponin I (cTnI) levels at 60 minutes and 24 hours.
Conducted histological tissue evaluations for infarction and utilized TUNEL staining to detect focal myocyte apoptosis at 60 minutes and 24 hours post-reperfusion.
Circulating cTnI exceeded baseline thresholds at 60 minutes post-reperfusion and reached readily detectable levels at 24 hours.
Tissue analysis showed no pathological evidence of infarction or necrosis, whereas TUNEL staining revealed isolated myocyte apoptosis at 60 minutes that was absent at 24 hours.

PICO

Population

Myocardial Ischemia

Intervention / Comparator

Brief myocardial ischemia

Primary Outcome

Cardiac Troponin I release and myocyte apoptosis

Discussion

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Implication

May indicate troponin release without infarction; leaves open translation to human transient ischemia.

Cite This Study

Weil et al. (2017) studied Myocardial Ischemia. Brief myocardial ischemia was evaluated on Cardiac Troponin I release and myocyte apoptosis. Brief myocardial ischemia in swine produced cardiac troponin I elevations and focal myocyte apoptosis at 60 minutes without pathological evidence of infarction.

synapsesocial.com/papers/6a0909540465d979db9d15de https://doi.org/10.1016/j.jacbts.2017.01.006

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Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine

Key Points

PICO

Discussion

Implication

Cite This Study

Brief Myocardial Ischemia Produces Cardiac Troponin I Release and Focal Myocyte Apoptosis in the Absence of Pathological Infarction in Swine

Key Points

PICO

Discussion

Implication

Cite This Study

Also Consider

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