A single high-intensity interval training session prior to a 2.6 mmol/L hypoglycemic clamp reduced hypoglycemia symptoms in type 1 diabetes patients with normal, but not impaired, awareness.
RCT (n=30)
Crossover
Does a single session of high-intensity interval training reduce awareness of subsequent hypoglycemia and attenuate cognitive dysfunction in patients with type 1 diabetes?
A single session of HIIT acutely reduces awareness of subsequent hypoglycemia in type 1 diabetes patients with normal awareness, while attenuating cognitive dysfunction.
High-intensity interval training (HIIT) has gained increasing popularity in patients with diabetes. HIIT acutely increases plasma lactate levels. This may be important, since the administration of lactate during hypoglycemia suppresses symptoms and counterregulation while preserving cognitive function. We tested the hypothesis that, in the short term, HIIT reduces awareness of hypoglycemia and attenuates hypoglycemia-induced cognitive dysfunction. In a randomized crossover trial, patients with type 1 diabetes and normal awareness of hypoglycemia (NAH), patients with impaired awareness of hypoglycemia (IAH), and healthy participants (n = 10 per group) underwent a hyperinsulinemic-hypoglycemic (2.6 mmol/L) clamp, either after a HIIT session or after seated rest. Compared with rest, HIIT reduced symptoms of hypoglycemia in patients with NAH but not in healthy participants or patients with IAH. HIIT attenuated hypoglycemia-induced cognitive dysfunction, which was mainly driven by changes in the NAH subgroup. HIIT suppressed cortisol and growth hormone responses, but not catecholamine responses to hypoglycemia. The present findings demonstrate that a single HIIT session rapidly reduces awareness of subsequent hypoglycemia in patients with type 1 diabetes and NAH, but does not in patients with IAH, and attenuates hypoglycemia-induced cognitive dysfunction. The role of exercise-induced lactate in mediating these effects, potentially serving as an alternative fuel for the brain, should be further explored.
Rooijackers et al. (Tue,) conducted a rct in Type 1 diabetes (n=30). High-intensity interval training (HIIT) vs. Seated rest was evaluated on Symptoms of hypoglycemia and hypoglycemia-induced cognitive dysfunction. A single high-intensity interval training session prior to a 2.6 mmol/L hypoglycemic clamp reduced hypoglycemia symptoms in type 1 diabetes patients with normal, but not impaired, awareness.