An early invasive strategy showed no benefit over a selective invasive strategy for the 10-year composite of death or spontaneous MI (33.8% vs. 29.0%; HR 1.12; 95% CI 0.97-1.46; p=0.11).
RCT (n=1,200)
randomized
Yes
Does an early invasive strategy reduce the 10-year composite of death or spontaneous MI in patients with NSTE-ACS and elevated cardiac troponin T compared to a selective invasive strategy?
At 10 years, an early invasive strategy offered no benefit over a selective invasive strategy for death or spontaneous MI in NSTE-ACS patients with elevated troponin T, but increased procedure-related MIs.
Effect estimate: HR 1.12 (95% CI 0.97 to 1.46)
Absolute Event Rate: 33.8% vs 29%
p-value: p=0.11
BACKGROUND: The ICTUS (Invasive Versus Conservative Treatment in Unstable Coronary Syndromes) trial compared early invasive strategy with a selective invasive strategy in patients with non-ST-segment elevation acute coronary syndrome (NSTE-ACS) and an elevated cardiac troponin T. No long-term benefit of an early invasive strategy was found at 1 and 5 years. OBJECTIVES: The aim of this study was to determine the 10-year clinical outcomes of an early invasive strategy versus a selective invasive strategy in patients with NSTE-ACS and an elevated cardiac troponin T. METHODS: The ICTUS trial was a multicenter, randomized controlled clinical trial that included 1,200 patients with NSTE-ACS and an elevated cardiac troponin T. Enrollment was from July 2001 to August 2003. We collected 10-year follow-up of death, myocardial infarction (MI), and revascularization through the Dutch population registry, patient phone calls, general practitioners, and hospital records. The primary outcome was the 10-year composite of death or spontaneous MI. Additional outcomes included the composite of death or MI, death, MI (spontaneous and procedure-related), and revascularization. RESULTS: Ten-year death or spontaneous MI was not statistically different between the 2 groups (33.8% vs. 29.0%, hazard ratio HR: 1.12; 95% confidence interval CI: 0.97 to 1.46; p = 0.11). Revascularization occurred in 82.6% of the early invasive group and 60.5% in the selective invasive group. There were no differences in additional outcomes, except for a higher rate of death or MI in the early invasive group compared with the rates for the selective invasive group (37.6% vs. 30.5%; HR: 1.30; 95% CI: 1.07 to 1.58; p = 0.009), driven by a higher rate of procedure-related MI in the early invasive group (6.5% vs. 2.4%; HR: 2.82; 95% CI: 1.53 to 5.20; p = 0.001). CONCLUSIONS: In patients with NSTE-ACS and elevated cardiac troponin T levels, an early invasive strategy has no benefit over a selective invasive strategy in reducing the 10-year composite outcome of death or spontaneous MI, and a selective invasive strategy may be a viable option in selected patients.
Hoedemaker et al. (Sat,) conducted a rct in non-ST-segment elevation acute coronary syndrome (NSTE-ACS) (n=1,200). Early invasive strategy vs. Selective invasive strategy was evaluated on 10-year composite of death or spontaneous MI (HR 1.12, 95% CI 0.97 to 1.46, p=0.11). An early invasive strategy showed no benefit over a selective invasive strategy for the 10-year composite of death or spontaneous MI (33.8% vs. 29.0%; HR 1.12; 95% CI 0.97-1.46; p=0.11).
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