In vivo 3D magnetic resonance elastography detected increased stiffness in infarcted compared to remote myocardium (4.6 ± 0.7 kPa vs 3.0 ± 0.6 kPa, P=0.02) in a porcine model of myocardial infarction.
Absolute Event Rate: 4.6% vs 3%
p-value: p=0.02
PURPOSE: The stiffness of a myocardial infarct affects the left ventricular pump function and remodeling. Magnetic resonance elastography (MRE) is a noninvasive imaging technique for measuring soft-tissue stiffness in vivo. The purpose of this study was to investigate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE in a porcine model of myocardial infarction, and compare the results with ex vivo uniaxial tensile testing. METHODS: Myocardial infarct was induced in a porcine model by embolizing the left circumflex artery. Fourteen days postinfarction, MRE imaging was performed in diastole using an echocardiogram-gated spin-echo echo-planar-imaging sequence with 140-Hz vibrations and 3D MRE processing. The MRE stiffness and tensile modulus from uniaxial testing were compared between the remote and infarcted myocardium. RESULTS: Myocardial infarcts showed increased in vivo MRE stiffness compared with remote myocardium (4.6 ± 0.7 kPa versus 3.0 ± 0.6 kPa, P = 0.02) within the same pig. Ex vivo uniaxial mechanical testing confirmed the in vivo MRE results, showing that myocardial infarcts were stiffer than remote myocardium (650 ± 80 kPa versus 110 ± 20 kPa, P = 0.01). CONCLUSIONS: These results demonstrate the feasibility of assessing in vivo regional myocardial stiffness with high-frequency 3D cardiac MRE. Magn Reson Med 79:361-369, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Arunachalam et al. (Wed,) conducted a other in Myocardial infarction. 3D magnetic resonance elastography (MRE) vs. Remote myocardium was evaluated on In vivo MRE stiffness (p=0.02). In vivo 3D magnetic resonance elastography detected increased stiffness in infarcted compared to remote myocardium (4.6 ± 0.7 kPa vs 3.0 ± 0.6 kPa, P=0.02) in a porcine model of myocardial infarction.