The v PIVOT MRI technique quantified muscle oxygen consumption without significant measurement bias compared to stand-alone sequences, yielding a peak consumption of 15.2 ± 6.7 mL O2/min/100 g.
Observational (n=15)
The v PIVOT MRI technique successfully measures macro- and microvascular blood flow and oxygen saturation to quantify skeletal muscle oxygen consumption.
Purpose To investigate the relationship between blood flow and oxygen consumption in skeletal muscle, a technique called “Velocity and Perfusion, Intravascular Venous Oxygen saturation and ” ( v PIVOT) is presented. v PIVOT allows the quantification of feeding artery blood flow velocity, perfusion, draining vein oxygen saturation, and muscle , all at 4‐s temporal resolution. Together, the measurement of blood flow and oxygen extraction can yield muscle oxygen consumption ( ) via the Fick principle. Methods In five subjects, v PIVOT‐derived results were compared with those obtained from stand‐alone sequences during separate ischemia‐reperfusion paradigms to investigate the presence of measurement bias. Subsequently, in 10 subjects, v PIVOT was applied to assess muscle hemodynamics and following a bout of dynamic plantar flexion contractions. Results From the ischemia‐reperfusion paradigm, no significant differences were observed between data from v PIVOT and comparison sequences. After exercise, the macrovascular flow response reached a maximum 8 ± 3 s after relaxation; however, perfusion in the gastrocnemius muscle continued to rise for 101 ± 53 s. Peak calculated based on mass‐normalized arterial blood flow or perfusion was 15.2 ± 6.7 mL O 2 /min/100 g or 6.0 ± 1.9 mL O 2 /min/100 g, respectively. Conclusions v PIVOT is a new method to measure blood flow and oxygen saturation, and therefore to quantify muscle oxygen consumption. Magn Reson Med 79:846–855, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Englund et al. (Thu,) reported a observational. v PIVOT MRI technique vs. stand-alone MRI sequences was evaluated on Measurement bias between v PIVOT and stand-alone sequences. The v PIVOT MRI technique quantified muscle oxygen consumption without significant measurement bias compared to stand-alone sequences, yielding a peak consumption of 15.2 ± 6.7 mL O2/min/100 g.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: