Current cigarette smoking was significantly associated with higher odds of subclinical atherosclerosis, including an ankle-brachial index ≤1.0 (OR 2.52; 95% CI 2.06-3.08; P<0.001).
Cross-Sectional (n=14,103)
Does cigarette smoking increase markers of subclinical inflammation and atherosclerosis in adults without clinical cardiovascular disease?
Cigarette smoking is strongly associated with increased markers of subclinical inflammation and atherosclerosis, including hsCRP, carotid intima-media thickness, abnormal ankle-brachial index, and coronary artery calcium, in adults without clinical cardiovascular disease.
Odds Ratio: 2.52 (95% CI 2.06–3.08)
p-value: p=<0.001
Background There is a need to identify sensitive biomarkers of early tobacco‐related cardiovascular disease. We examined the association of smoking status, burden, time since quitting, and intensity, with markers of inflammation and subclinical atherosclerosis. Methods and Results We studied 14 103 participants without clinical cardiovascular disease in ELSA‐Brasil (Brazilian Longitudinal Study of Adult Health). We evaluated baseline cross‐sectional associations between smoking parameters and inflammation (high‐sensitivity C‐reactive protein hs CRP ) and measures of subclinical atherosclerosis (carotid intima–media thickness, ankle‐brachial index, and coronary artery calcium CAC ). The cohort included 1844 current smokers, 4121 former smokers, and 8138 never smokers. Mean age was 51.7±8.9 years; 44.8% were male. After multivariable adjustment, compared with never smokers, current smokers had significantly higher levels of hs CRP (β=0.24, 0.19–0.29 mg/L; P 0 (odds ratio: 1.83; 95% confidence interval, 1.46–2.30; P 0 were lower with increasing time since quitting ( P 0 ( P =0.03) after adjusting for duration of smoking. Conclusions Strong associations were observed between smoking status, burden, and intensity with inflammation (hs CRP ) and subclinical atherosclerosis (carotid intima–media thickness, ankle‐brachial index, CAC ). These markers of early cardiovascular disease injury may be used for the further study and regulation of traditional and novel tobacco products.
Kianoush et al. (Sun,) conducted a cross-sectional in Subclinical inflammation and atherosclerosis (n=14,103). Cigarette smoking vs. Never smokers was evaluated on ankle-brachial index ≤1.0 (OR 2.52, 95% CI 2.06-3.08, p=<0.001). Current cigarette smoking was significantly associated with higher odds of subclinical atherosclerosis, including an ankle-brachial index ≤1.0 (OR 2.52; 95% CI 2.06-3.08; P<0.001).
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