Does a combined multi-parametric approach with ECV and LGE better stratify myocardial fibrosis patterns in patients with severe aortic stenosis compared to single parameters?
A multi-parametric CMR approach combining ECV and LGE is necessary to comprehensively assess the complex patterns of myocardial fibrosis in severe aortic stenosis.
Myocardial fibrosis in severe AS is complex, but three main patterns exist: endocardial fibrosis, microscars (mainly in the subendomyocardium), and diffuse interstitial fibrosis. Neither histological CVF nor the CMR parameters ECV and LGE capture fibrosis in its totality. A combined, multi-parametric approach with ECV and LGE allows best stratification of AS patients according to the response of the myocardial collagen matrix.
Treibel et al. (Fri,) studied this question.
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