Higher fasting plasma glucose levels were independently associated with elevated mean carotid intima-media thickness, with each 1-mmol/L increase in FPG resulting in a 2.75-μm increase in mean CIMT.
Cross-Sectional (n=3,509)
Is elevated fasting plasma glucose associated with increased carotid intima-media thickness in non-diabetic adults?
Fasting plasma glucose is an independent determinant of mean carotid intima-media thickness in a non-diabetic population, highlighting the importance of glycemic control in preventing atherosclerosis.
Mean Difference: 2.75 (95% CI 0.07–5.43)
p-value: p=0.044
// Yalin Guan 1, * , Changshen Yu 1, * , Min Shi 2, 3 , Jingxian Ni 2, 3 , Yanan Wu 2, 3 , Hongfei Gu 4 , Lingling Bai 2, 3 , Jie Liu 2, 3 , Jun Tu 2, 3, 5 , Jinghua Wang 2, 3, 5, 6 and Xianjia Ning 2, 3, 5, 6 1 Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China 2 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China 3 Department of Epidemiology, Tianjin Neurological Institute, Tianjin, China 4 Department of Neurology, Tianjin Haibin People’s Hospital, Tianjin, China 5 Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China 6 Central of Clinical Epidemiology, Tianjin Medical University General Hospital, Tianjin, China * These authors have contributed equally to this work Correspondence to: Yalin Guan, email: guanyalinhh@126.com Xianjia Ning, email: xjn0906@gmail.com , xning@tmu.edu.cn Keywords: carotid intima media thickness; fasting plasma glucose; risk factors; ultrasonography; epidemiology Received: March 07, 2017 Accepted: October 12, 2017 Published: November 06, 2017 ABSTRACT We assessed the association between the mean carotid intima-media thickness (CIMT) and fasting plasma glucose (FPG) levels in a low-income population in rural China. Adults aged ≥45 years without a history of diabetes, stroke, or cardiovascular disease were recruited. All participants were categorized into four groups according to FPG level. A total of 3509 participants were analyzed in this study. In the univariate analysis, sex, age, education level, hypertension, central obesity, current smoking, alcohol consumption, and higher levels of FPG, total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) were associated with mean CIMT and frequency of increased CIMT. FPG levels were significantly associated with mean CIMT; each 1-mmol/L increase in FPG resulted in a 2.75-μm increase in mean CIMT when adjusted by age, sex, education level, current smoking status, alcohol consumption, hypertension, and the levels of TC, TG, HDL-C, and LDL-C (P = 0.044). However, the association between FPG and the frequency of increased CIMT disappeared after adjusting by covariates. These findings indicate that FPG is an independent determinant of mean CIMT in a non-diabetic population. Management and control of FPG levels is crucial for preventing atherosclerosis in populations with high stroke risks in China.
Guan et al. (Mon,) conducted a cross-sectional in Non-diabetic adults (n=3,509). Fasting plasma glucose (FPG) levels vs. Lower FPG levels was evaluated on Mean carotid intima-media thickness (CIMT) (MD 2.75, 95% CI 0.07-5.43, p=0.044). Higher fasting plasma glucose levels were independently associated with elevated mean carotid intima-media thickness, with each 1-mmol/L increase in FPG resulting in a 2.75-μm increase in mean CIMT.