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A novel 65.8-kb multidrug resistance transposon, designated Tn6450, was characterized in a Proteus mirabilis isolate from chicken in China. Tn6450 contains 18 different antimicrobial resistance genes, including cephalosporinase gene blaDHA-1 and fluoroquinolone resistance genes qnrA1 and aac(6')-Ib-cr It carries a class 1/2 hybrid integron composed of intI2 and a 3' conserved segment of the class 1 integron. Tn6450 is derived from Tn7 via acquisition of new mobile elements and resistance genes.
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Yanpeng Chen
University of California, Los Angeles
Changwei Lei
Ministry of Education of the People's Republic of China
Linghan Kong
Chongqing University
Antimicrobial Agents and Chemotherapy
Sichuan University
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Chen et al. (Thu,) studied this question.
synapsesocial.com/papers/69de5192e02db3e29db0c072 — DOI: https://doi.org/10.1128/aac.02192-17