March 16, 2018Open Access
Arterial stiffness and dementia pathology
Key Result
Arterial stiffness, measured by pulse wave velocity, is an emerging risk factor for dementia through its relationships with cognition, cerebral small vessel disease, and β-amyloid deposition.
Study Design
Type
Observational
PICO
Population
Dementia pathology
Intervention / Comparator
Arterial stiffness (Pulse Wave Velocity)
Primary Outcome
Cognition, cerebral small vessel disease (cSVD), and β-amyloid (Aβ) deposition
Abstract
OBJECTIVE: Arterial stiffness has been associated with evidence of cerebral small vessel disease (cSVD) and fibrillar β-amyloid (Aβ) deposition in the brain. These complex relationships have not been examined in racially and cognitively diverse cohorts. METHODS: ε4 status, and cognition. RESULTS: ε4 status. CONCLUSIONS: Arterial stiffness, measured by PWV, is an emerging risk factor for dementia through its repeated relationships with cognition, cSVD, and Aβ deposition.
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Authors
T
Timothy M. Hughes
Vascular Medicine
Lynne E. Wagenknecht
Preventive Cardiology
S
Suzanne Craft
Wake Forest University
Journals
Neurology
Actions
Institutions
Johns Hopkins University
University of North Carolina at Chapel Hill
Johns Hopkins Medicine
References and Citations
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