Key result
Arterial stiffness is linked to dementia risk through cognition, cSVD, and Aβ deposition.
Why the study?
Is arterial stiffness associated with cognition, cerebral small vessel disease, and β-amyloid deposition?
Observational
Is arterial stiffness associated with cognition, cerebral small vessel disease, and β-amyloid deposition?
Arterial stiffness measured by pulse wave velocity is associated with dementia pathology, including cerebral small vessel disease and amyloid deposition.
Answers are grounded in this paper and cite their sources.
Supports vascular risk monitoring in cognitive decline; leaves open whether PWV modification alters dementia risk.
OBJECTIVE: Arterial stiffness has been associated with evidence of cerebral small vessel disease (cSVD) and fibrillar β-amyloid (Aβ) deposition in the brain. These complex relationships have not been examined in racially and cognitively diverse cohorts. METHODS: ε4 status, and cognition. RESULTS: ε4 status. CONCLUSIONS: Arterial stiffness, measured by PWV, is an emerging risk factor for dementia through its repeated relationships with cognition, cSVD, and Aβ deposition.
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Hughes et al. (2018) conducted an observational in Dementia pathology. Arterial stiffness (Pulse Wave Velocity) was evaluated on Cognition, cerebral small vessel disease (cSVD), and β-amyloid (Aβ) deposition. Arterial stiffness, measured by pulse wave velocity, is an emerging risk factor for dementia through its relationships with cognition, cerebral small vessel disease, and β-amyloid deposition.
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