January 23, 2018Open Access

Hepatic stellate cell–derived platelet‐derived growth factor receptor‐alpha‐enriched extracellular vesicles promote liver fibrosis in mice through SHP2

EKEnis KostallariMayo Clinic PHPetra HirsovaMayo Clinic APAlena PrašnickáUniversité Libre de Bruxelles

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Abstract

PDGFRα is enriched in EVs derived from PDGF-BB-treated HSCs in an Src homology 2 domain tyrosine phosphatase 2-dependent manner and these PDGFRα-enriched EVs participate in development of liver fibrosis. (Hepatology 2018;68:333-348).

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