March 27, 2018Open Access

Social isolation and loneliness as risk factors for myocardial infarction, stroke and mortality: UK Biobank cohort study of 479 054 men and women

CHChristian HakulinenUniversity of Helsinki LPLaura Pulkki-RåbäckUniversity of Helsinki MVMarianna VirtanenUniversity of Eastern Finland

Structured PICO

Do social isolation and loneliness increase the risk of myocardial infarction, stroke, and mortality?

Population

479,054 men and women from the UK Biobank cohort

Intervention

Social isolation and loneliness (exposure)

Comparator

Lack of social isolation and loneliness

Outcome

Myocardial infarction, stroke, and mortalityhard clinical

While social isolation and loneliness are associated with an increased risk of cardiovascular events and mortality, this association is largely driven by conventional risk factors.

Abstract

Isolated and lonely persons are at increased risk of AMI and stroke, and, among those with a history of AMI or stroke, increased risk of death. Most of this risk was explained by conventional risk factors.

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