What question did this study set out to answer?

This research investigates the link between baseline LDL-C levels and mortality rates following LDL-C lowering therapies.

April 17, 2018Open Access

Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering

Key Points

This research investigates the link between baseline LDL-C levels and mortality rates following LDL-C lowering therapies.
Conducted meta-analyses and meta-regressions on trials involving patients with varying LDL-C levels.
Compared intensive vs. less intensive LDL-C lowering in relation to mortality outcomes.
Intensive LDL-C lowering significantly reduced total and cardiovascular mortality in patients with higher baseline LDL-C levels (≥100 mg/dL).
No significant mortality benefit was found for patients with baseline LDL-C levels below 100 mg/dL.

Abstract

In these meta-analyses and meta-regressions, more intensive compared with less intensive LDL-C lowering was associated with a greater reduction in risk of total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels. This association was not present when baseline LDL-C level was less than 100 mg/dL, suggesting that the greatest benefit from LDL-C-lowering therapy may occur for patients with higher baseline LDL-C levels.

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Discussion

Journals

JAMA

Institutions

University of Iowa

University of Alberta

Nicolaus Copernicus University

References and Citations

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