What question did this study set out to answer?

This research investigates the link between baseline LDL-C levels and mortality rates following LDL-C lowering therapies.

April 17, 2018Open Access

Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering

Key Points

This research investigates the link between baseline LDL-C levels and mortality rates following LDL-C lowering therapies.
Conducted meta-analyses and meta-regressions on trials involving patients with varying LDL-C levels.
Compared intensive vs. less intensive LDL-C lowering in relation to mortality outcomes.
Intensive LDL-C lowering significantly reduced total and cardiovascular mortality in patients with higher baseline LDL-C levels (≥100 mg/dL).
No significant mortality benefit was found for patients with baseline LDL-C levels below 100 mg/dL.

Abstract

In these meta-analyses and meta-regressions, more intensive compared with less intensive LDL-C lowering was associated with a greater reduction in risk of total and cardiovascular mortality in trials of patients with higher baseline LDL-C levels. This association was not present when baseline LDL-C level was less than 100 mg/dL, suggesting that the greatest benefit from LDL-C-lowering therapy may occur for patients with higher baseline LDL-C levels.

Bookmark

View Full Paper

Cite This Study

Navarese et al. (Tue,) studied this question.

synapsesocial.com/papers/69d56c3e75589c71d767cd1e https://doi.org/https://doi.org/10.1001/jama.2018.2525

Bookmark

View Full Paper