Correlation with Invasive Left Ventricular Filling Pressures and Prognostic Relevance of the Echocardiographic Diastolic Parameters Used in the 2016 Esc Heart Failure Guidelines and in the 2016 Ase/Eacvi Recommendations: A Systematic Review in Patients with Heart Failure with Preserved Ejection Fraction

Structured PICO

Do echocardiographic diastolic parameters correlate with invasive left ventricular filling pressures and outcomes in patients with HFpEF?

Population

Patients with Heart Failure with Preserved Ejection Fraction (HFpEF)

Intervention

Echocardiographic diastolic parameters at rest (specifically E/e' as per 2016 ESC and ASE/EACVI guidelines)

Comparator

Invasive left ventricular filling pressures

Outcome

Correlation with invasive filling pressures and outcomessurrogate

The widely used echocardiographic parameter E/e' has only modest correlation with invasive filling pressures and outcomes in HFpEF, suggesting limitations in current non-invasive diagnostic criteria.

Abstract

Only a small number of studies validated the use of echocardiographic parameters at rest in patients with HFpEF. The best established parameter appears to be E/e', but the existing data only show modest correlations of E/e' with invasive filling pressures and outcomes in HFpEF.

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