The TRPM4 channel plays a key role in cardiovascular pathophysiology, including cardiac conduction disease and the development of cardiac ischemia-reperfusion injury.
The transient receptor potential cation channel subfamily M member 4 (TRPM4) channel influences calcium homeostasis during many physiological activities such as insulin secretion, immune response, respiratory reaction, and cerebral vasoconstriction. This calcium-activated, monovalent, selective cation channel also plays a key role in cardiovascular pathophysiology; for example, a mutation in the TRPM4 channel leads to cardiac conduction disease. Recently, it has been suggested that the TRPM4 channel is also involved in the development of cardiac ischemia-reperfusion injury, which causes myocardial infarction. In the present review, we discuss the physiological function of the TRPM4 channel, and assess its role in cardiovascular pathophysiology.
Wang et al. (Fri,) conducted a review in Cardiovascular pathophysiology. TRPM4 channel was evaluated. The TRPM4 channel plays a key role in cardiovascular pathophysiology, including cardiac conduction disease and the development of cardiac ischemia-reperfusion injury.