Patients with heart failure with preserved ejection fraction (HFpEF) in the absence of unrevascularized macrovascular CAD
Prevalence of coronary microvascular dysfunction (CMD) and its association with systemic endothelial dysfunction (RHI, UACR) and markers of HF severity (NTproBNP and RV dysfunction)surrogate
Coronary microvascular dysfunction is highly prevalent in HFpEF and correlates with systemic endothelial dysfunction and heart failure severity, highlighting it as a potential therapeutic target.
PROMIS-HFpEF is the first prospective multi-centre, multinational study to demonstrate a high prevalence of CMD in HFpEF in the absence of unrevascularized macrovascular CAD, and to show its association with systemic endothelial dysfunction (RHI, UACR) as well as markers of HF severity (NTproBNP and RV dysfunction). Microvascular dysfunction may be a promising therapeutic target in HFpEF.
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Shah et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69cff87247485ca0e310d8ad — DOI: https://doi.org/10.1093/eurheartj/ehy531
Sanjiv J. Shah
Carolyn S.P. Lam
Sara Svedlund
European Heart Journal
Northwestern University
Karolinska Institutet
National University of Singapore
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