September 1, 2018Open Access
View Full PaperValidation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study
Key Result
The Resting Full-cycle Ratio (RFR) is diagnostically equivalent to iFR and better detects significant coronary stenoses throughout the entire cardiac cycle.
Structured PICO
Does Resting Full-cycle Ratio (RFR) provide diagnostic equivalence to iFR in detecting physiologically significant coronary stenoses?
I
Intervention
Resting Full-cycle Ratio (RFR)
C
Comparator
iFR (instantaneous wave-free ratio)
O
Outcome
Diagnostic equivalence to iFR and ability to detect the lowest Pd/Pa during the full cardiac cyclesurrogate
RFR is a valid non-hyperemic index that is diagnostically equivalent to iFR but evaluates the full cardiac cycle, potentially identifying significant stenoses missed by segment-specific assessments.
Main Result
Absolute Event Rate: 0% vs 0%
Abstract
RFR is diagnostically equivalent to iFR but unbiased in its ability to detect the lowest Pd/Pa during the full cardiac cycle, potentially unmasking physiologically significant coronary stenoses that would be missed by assessment dedicated to specific segments of the cardiac cycle.