September 5, 2018Open Access

Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells

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Abstract

Collectively, our study reports molecular differences in IL-6 classic- and trans-signaling in human vascular endothelial cells; and elucidates the pathways which mediate MCP-1 induction by IL-6 trans-signaling.

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Authors

Mulugeta M. Zegeye

Madelene Lindkvist

Knut Fälker

Journals

Cell Communication and Signaling

SHILAP Revista de lepidopterología

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Institutions

Dalhousie University

Örebro University

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Activation of the JAK/STAT3 and PI3K/AKT pathways are crucial for IL-6 trans-signaling-mediated pro-inflammatory response in human vascular endothelial cells

Key Points

Abstract

Citation Network

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Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion

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