18F-JNJ-64413739, a Novel PET Ligand for the P2X7 Ion Channel: Radiation Dosimetry, Kinetic Modeling, Test-Retest Variability, and Occupancy of the P2X7 Antagonist JNJ-54175446

Key Points

• Evaluate the suitability of F-JNJ-64413739 as a PET ligand for quantifying P2X7 receptor expression in the brain.
• Kinetic modeling to assess radioligand behavior
• Radiation dosimetry analysis
• Test-retest variability evaluation
• F-JNJ-64413739 demonstrates effective visualization of P2X7 receptor expression
• Significant insights gained into P2X7 antagonists' target engagement
• Provides guidance for optimal dose selection in therapeutic applications