Randomized trial evaluates P2X7 receptor expression through PET imaging in humans, suggesting its use in drug development.
F-JNJ-64413739 is a suitable PET ligand for the quantification of P2X7R expression in the human brain. It can be used to provide insight into P2X7R expression in health and disease, to evaluate target engagement by P2X7 antagonists, and to guide dose selection.
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Koole et al. (2018) studied this question.
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