Baseline obesity (BMI ≥30 kg/m2) was associated with a higher risk of recurrent atrial fibrillation at 12 months compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011).
Observational (n=3,333)
Does elevated baseline BMI increase the risk of AF recurrence at 12 months following catheter ablation in patients with atrial fibrillation?
Baseline obesity (BMI ≥30 kg/m2) is associated with a higher risk of AF recurrence at 12 months following catheter ablation compared to being overweight, highlighting the potential importance of preprocedural weight management.
Effect estimate: HR 1.223 (95% CI 1.047 to 1.429)
p-value: p=0.011
Objectives The association between obesity and atrial fibrillation (AF) is well-established. We aimed to evaluate the impact of index body mass index (BMI) on AF recurrence at 12 months following catheter ablation using propensity-weighted analysis. In addition, periprocedural complications and fluoroscopy details were examined to assess overall safety in relationship to increasing BMI ranges. Methods Baseline, periprocedural and follow-up data were collected on consecutive patients scheduled for AF ablation. There were no specific exclusion criteria. Patients were categorised according to baseline BMI in order to assess the outcomes for each category. Results Among 3333 patients, 728 (21.8%) were classified as normal (BMI <25.0 kg/m 2 ), 1537 (46.1%) as overweight (BMI 25.5–29.0 kg/m 2 ) and 1068 (32.0%) as obese (BMI ≥30.0 kg/m 2 ). Procedural duration and radiation dose were higher for overweight and obese patients compared with those with a normal BMI (p=0.002 and p<0.001, respectively). An index BMI ≥30 kg/m 2 led to a 1.2-fold increased likelihood of experiencing recurrent AF at 12-months follow-up as compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011), while no significant correlation was found between overweight and normal BMI groups (HR 0.954; 95% CI 0.798 to 1.140; p=0.605) and obese versus normal BMI (HR 1.16; 95% CI 0.965 to 1.412; p=0.112). Conclusions Patients with a baseline BMI ≥30 kg/m 2 have a higher recurrence rate of AF following catheter ablation and therefore lifestyle modification to target obesity preprocedure should be considered in these patients.
Glover et al. (Tue,) conducted a observational in Atrial fibrillation (n=3,333). Obesity (BMI ≥30.0 kg/m2) vs. Overweight (BMI 25.5–29.0 kg/m2) and normal BMI (<25.0 kg/m2) was evaluated on AF recurrence at 12 months (HR 1.223, 95% CI 1.047 to 1.429, p=0.011). Baseline obesity (BMI ≥30 kg/m2) was associated with a higher risk of recurrent atrial fibrillation at 12 months compared with overweight patients (HR 1.223; 95% CI 1.047 to 1.429; p=0.011).