The ACE2 rs4646188 variant (TT + CT genotype) was significantly associated with an increased risk of essential hypertension (OR 3.25) compared to the CC genotype.
Case-Control (n=635)
Are ACE2 polymorphisms associated with susceptibility to essential hypertension, dyslipidemia, and ischemic stroke in individuals from Xinjiang, China?
Specific ACE2 polymorphisms, particularly the rs4646188 variant, are associated with increased genetic susceptibility to essential hypertension, dyslipidemia, and ischemic stroke in the Chinese Xinjiang population.
Odds Ratio: 3.25 (95% CI 1.95–5.41)
Absolute Event Rate: 78.9% vs 68.2%
p-value: p=<0.001
BACKGROUND: Cardiovascular benefits by reversing environmental risks factors for essential hypertension (EH) and dyslipidemia could be weaken by high genetic risk. We investigated possible associations between ACE2 polymorphisms and dyslipidemia in patients with EH. METHODS: Four hundred and two hypertensive patients were enrolled in an EH group and 233 normotensive individuals were enrolled as control group from the Xinjiang region of China. Fourteen ACE2 polymorphisms were genotyped by Matrix-assisted laser desorption ionization time-of-flight mass spectrometry. RESULTS: Participants carrying T allele (TT + CT) of rs2074192 (P = 0.006), rs4646155 (P = 0.030) and rs4646188 (P < 0.001), C allele (CT + CT or CC + CG) of rs4240157 (P = 0.012), rs4830542 (P = 0.020) and rs879922 (P < 0.001) and TT genotype of rs2106809 (P = 0.012) were associated with EH. Meanwhile,ACE2 SNPs also exhibited association with dyslipidemia but exhibited obvious heterogeneity. rs1978124 (TT + CT, P = 0.009), rs2106809 (TT, P = 0.045), rs233575 (CC + CT, P = 0.018), rs4646188 (CC, P = 0.011) and rs879922 (CC + CG, P = 0.003) were association with increased LDL-C (≥1.8 mmol/L). rs2106809 (CC + CT, P < 0.001), rs2285666(TT + CT, P = 0.017), rs4646142(CC + CG, P = 0.044), rs4646155(TT + CT, P < 0.001) and rs4646188(TT + CT, P = 0.033) were association with decreased HDL-C (< 1.0 mmol/L). rs2074192 (TT + CT, P = 0.012), rs4240157 (CC + CT, P = 0.027), rs4646156 (AA+AT, P = 0.007), rs4646188 (TT + CT, P = 0.005), rs4830542 (CC + CT, P = 0.047) and rs879922 (CC + CG, P = 0.001) were association with increased TC (≥5.2 mmol/L). rs2106809 (P = 0.034) and rs4646188 (P = 0.013) were associated with hypertriglyceridemia. Further, ischemic stroke was more prevalent with rs4240157 (CC + CT, P = 0.043), rs4646188 (CC + CT, P = 0.013) and rs4830542 (CC + CT, P = 0.037). In addition, rs2048683 and rs6632677 were not association with EH, dyslipidemia and ischemic stroke. CONCLUSION: The ACE2 rs4646188 variant may be a potential and optimal genetic susceptibility marker for EH, dyslipidemia and its related ischemic stroke.
Pan et al. (Sat,) conducted a case-control in Essential hypertension and dyslipidemia (n=635). ACE2 rs4646188 variant (TT + CT genotype) vs. ACE2 rs4646188 CC genotype was evaluated on Essential hypertension (OR 3.25, 95% CI 1.95-5.41, p=<0.001). The ACE2 rs4646188 variant (TT + CT genotype) was significantly associated with an increased risk of essential hypertension (OR 3.25) compared to the CC genotype.
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