Patients undergoing transvenous lead extraction for infective indications had significantly higher 30-day mortality compared to those with noninfective indications (4.0% vs 0.2%, P<0.001).
Cohort (n=925)
Does the indication for transvenous lead extraction (infective vs noninfective, systemic vs local) affect the risk of 30-day mortality and major complications?
Patients undergoing transvenous lead extraction for infective indications, particularly systemic infections, have a significantly higher risk of 30-day mortality and major complications compared to those with noninfective or local infective indications.
Absolute Event Rate: 4% vs 0.2%
p-value: p=<0.001
BACKGROUND: Transvenous lead extraction (TLE) may be necessary due to infective and noninfective indications. We aim to identify predictors of 30-day mortality and risk factors between infective versus noninfective groups and systemic versus local infection subgroups. METHODS: A total of 925 TLEs between October 2000 and December 2016 were prospectively collected and dichotomized (infective group n = 505 vs noninfective group n = 420 and systemic infection n = 164 vs local infection n = 341). RESULTS: All-cause major complication including deaths was significantly higher (5.1%, n = 26 vs 1.2%, n = 5, P = 0.001) as well as 30-day mortality (4.0%, n = 20 vs 0.2%, n = 1, P < 0.001) in the infective group compared to the noninfective group. Both subgroups (systemic vs local infection) were balanced for demographics. All-cause major complication including deaths was significantly higher (9.1%, n = 15 vs 3.2%, n = 11, P = 0.008) as well as all-cause 30-day mortality (7.9%, n = 13 vs 2.1%, n = 7, P = 0.003) in the systemic infection subgroup compared to the local infection subgroup. CONCLUSION: Patients undergoing TLE for infective indications are at greater risk of 30-day all-cause mortality compared to noninfective patients. Patients undergoing TLE for systemic infective indications are at greater risk of 30-day all-cause mortality compared to patients with local infection. Renal impairment, systemic infection, and elevated preprocedure C-reactive protein are independent predictors of 30-day all-cause mortality in patients undergoing TLE for an infective indication.
Gould et al. (Fri,) conducted a cohort in Transvenous lead extraction (n=925). Infective indication for transvenous lead extraction vs. Noninfective indication was evaluated on 30-day mortality (p=<0.001). Patients undergoing transvenous lead extraction for infective indications had significantly higher 30-day mortality compared to those with noninfective indications (4.0% vs 0.2%, P<0.001).