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Microwave-assisted copper-catalyzed cascade reactions between 2-halobenzoic acids and amidines to synthesize quinazolinone derivatives in water are reported. A variety of target products were obtained in good to excellent yields up to 94%. Its application was performed by the synthesis of 4-(1H-benzodimidazol-2-ylthio)-6-methoxypteridine, which displayed significant anti-proliferation effect.
Ke et al. (Fri,) studied this question.