An atrial fibrillation polygenic risk score was significantly associated with cardioembolic stroke (OR per SD 1.40; p=1.45×10^-48), independent of clinical risk factors.
Observational (n=34,216)
Yes
Is an atrial fibrillation polygenic risk score associated with cardioembolic stroke risk independent of clinical risk factors?
Genetic risk for atrial fibrillation is strongly associated with cardioembolic stroke independent of clinical risk factors, suggesting its potential utility as a biomarker for AF-related strokes.
Effect estimate: OR 1.40
p-value: p=1.45 × 10^-48
Objective We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain cardioembolic stroke risk. Methods We evaluated genetic correlations between a previous genetic study of AF and AF in the presence of cardioembolic stroke using genome-wide genotypes from the Stroke Genetics Network (N = 3,190 AF cases, 3,000 cardioembolic stroke cases, and 28,026 referents). We tested whether a previously validated AF polygenic risk score (PRS) associated with cardioembolic and other stroke subtypes after accounting for AF clinical risk factors. Results We observed a strong correlation between previously reported genetic risk for AF, AF in the presence of stroke, and cardioembolic stroke (Pearson r = 0.77 and 0.76, respectively, across SNPs with p −4 in the previous AF meta-analysis). An AF PRS, adjusted for clinical AF risk factors, was associated with cardioembolic stroke (odds ratio OR per SD = 1.40, p = 1.45 × 10−48), explaining ∼20% of the heritable component of cardioembolic stroke risk. The AF PRS was also associated with stroke of undetermined cause (OR per SD = 1.07, p = 0.004), but no other primary stroke subtypes (all p > 0.1). Conclusions Genetic risk of AF is associated with cardioembolic stroke, independent of clinical risk factors. Studies are warranted to determine whether AF genetic risk can serve as a biomarker for strokes caused by AF.
Pulit et al. (Sat,) conducted a observational in Cardioembolic stroke and atrial fibrillation (n=34,216). Atrial fibrillation polygenic risk score (PRS) vs. Referents was evaluated on Cardioembolic stroke (OR 1.40, p=1.45 × 10^-48). An atrial fibrillation polygenic risk score was significantly associated with cardioembolic stroke (OR per SD 1.40; p=1.45×10^-48), independent of clinical risk factors.
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