Does a favorable lifestyle reduce the risk of coronary artery disease in participants at high genetic risk?
55,685 participants across four studies assessed for genetic risk and lifestyle factors
Favorable lifestyle
Unfavorable lifestyle
Coronary artery diseasehard clinical
Adherence to a healthy lifestyle is associated with a substantially reduced risk of coronary artery disease, even among individuals with a high genetic risk.
Across four studies involving 55,685 participants, genetic and lifestyle factors were independently associated with susceptibility to coronary artery disease. Among participants at high genetic risk, a favorable lifestyle was associated with a nearly 50% lower relative risk of coronary artery disease than was an unfavorable lifestyle. (Funded by the National Institutes of Health and others.).
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Khera et al. (Sun,) studied this question.
synapsesocial.com/papers/69d576db62196bac97d9bcd6 — DOI: https://doi.org/10.1056/nejmoa1605086
Amit V. Khera
Preventive Cardiology
Connor A. Emdin
Preventive Cardiology
Isabel Drake
Malmö University
New England Journal of Medicine
University of Pennsylvania
Brigham and Women's Hospital
Massachusetts General Hospital
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