Serum NT-proBNP levels alone predicted 5-year incident heart failure with an AUC of 0.79 (95% CI 0.74-0.83), similar to a 7-parameter multivariable model (AUC 0.82, P=0.035).
Cohort (n=3,842)
Do age-specific serum NT-proBNP levels predict incident heart failure in individuals aged ≥ 60 years at increased cardiovascular risk?
Age-specific serum NT-proBNP levels can effectively predict 5-year incident heart failure in individuals aged ≥ 60 years at increased cardiovascular risk.
Effect estimate: AUC 0.79 (95% CI 0.74-0.83)
p-value: p=0.035
AIMS: We investigated which serum amino-terminal pro-B-type-natriuretic peptide (NT-proBNP) levels inform heart failure (HF) risk in a community-based population at increased cardiovascular disease (CVD) risk. METHODS AND RESULTS: Inclusion criteria were age ≥ 60 years with one or more of self-reported hypertension, diabetes, heart disease, abnormal heart rhythm, cerebrovascular disease, or renal impairment. Exclusion criteria were known HF, ejection fraction (EF) 76% and specificities of 47-69% for 5-year prediction of total HF in men and women in all three age groups. Sensitivities were ≥ 75% in most subgroups according to body mass index, estimated glomerular filtration rate, and the presence or absence of atrial fibrillation, pacemaker, or CVD, and for the prediction of HFpEF, HFrEF and VHF. CONCLUSION: Age-specific serum NT-proBNP levels inform prognosis, and hence therapeutic decisions, regarding HF risk in individuals at increased CVD risk.
Campbell et al. (Fri,) conducted a cohort in Increased cardiovascular disease risk (n=3,842). Serum amino-terminal pro-B-type-natriuretic peptide (NT-proBNP) level vs. 7-parameter multivariable model was evaluated on 5-year prediction of total heart failure (AUC 0.79, 95% CI 0.74-0.83, p=0.035). Serum NT-proBNP levels alone predicted 5-year incident heart failure with an AUC of 0.79 (95% CI 0.74-0.83), similar to a 7-parameter multivariable model (AUC 0.82, P=0.035).
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