Do triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants reduce the risk of coronary heart disease?
Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants
Risk of Coronary Heart Disease (CHD)hard clinical
The clinical benefit of lowering triglyceride and LDL-C levels appears to be proportional to the absolute change in ApoB.
Triglyceride-lowering LPL variants and LDL-C-lowering LDLR variants were associated with similar lower risk of CHD per unit difference in ApoB. Therefore, the clinical benefit of lowering triglyceride and LDL-C levels may be proportional to the absolute change in ApoB.
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Brian A. Ference
John J.P. Kastelein
Kausik K. Ray
JAMA
ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam)
Harvard University
Columbia University
University of Cambridge
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Ference et al. (Tue,) studied this question.
www.synapsesocial.com/papers/69cdfe8c3d84e1f5ff46c483 — DOI: https://doi.org/10.1001/jama.2018.20045